Description

1-Octadecanoyl-2-[cis-9,12-Octadecadienoyl]-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid of significant interest in advanced biochemical and pharmaceutical research. This compound, commonly known as a specific phosphatidylcholine (PC) species, is valued for its role as a critical building block in the formulation of lipid-based delivery systems. It is essential for researchers and manufacturers in the life sciences sector, particularly those developing liposomes, lipid nanoparticles (LNPs), and other model membrane systems for drug delivery, diagnostics, and cosmetic applications.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural phospholipid for creating stable, uniform vesicles for encapsulating active pharmaceutical ingredients (APIs), mRNA vaccines, and nutraceuticals.
• Biomembrane & Model Membrane Research: Used to construct artificial bilayers and vesicles (e.g., giant unilamellar vesicles, GUVs) for studying membrane biophysics, protein-lipid interactions, and cellular processes.
• Drug Delivery Systems: A critical excipient in the development of targeted and sustained-release drug delivery platforms to enhance therapeutic efficacy and reduce side effects.
• Cosmetic & Dermal Applications: Incorporated into high-end cosmetic formulations as a skin-identical lipid to improve skin barrier function, hydration, and the delivery of active cosmetic ingredients.
• Biochemical Standards & Reagents: Serves as a pure reference standard in analytical laboratories for lipidomics research, quality control, and method development.
• Cell Culture & Media Supplements: Used as a component in specialized serum-free media and supplements to support the growth of sensitive cell lines.

Basic Information

Product Name	1-Octadecanoyl-2-[cis-9,12-Octadecadienoyl]-Sn-Glycero-3-Phosphocholine
CAS No.	18468-68-3
Molecular Formula	C44H84NO8P
Molecular Weight	786.10 g/mol
Synonyms	PC(18:0/18:2(9Z,12Z)); 1-Stearoyl-2-Linoleoyl-sn-Glycero-3-Phosphocholine; SLP; 18:0-18:2 PC; Phosphatidylcholine (18:0/18:2(9Z,12Z)); 1-Octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; (2R)-2,3-Bis[[(9Z,12Z)-octadeca-9,12-dienoyl]oxy]propyl 2-(trimethylazaniumyl)ethyl phosphate
EINECS	Contact for details

Quality Control

Our 1-Octadecanoyl-2-[cis-9,12-Octadecadienoyl]-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and formulation. A comprehensive Certificate of Analysis (COA) detailing purity, solvent residues, and other critical parameters is provided with every shipment to guarantee traceability and consistency for your applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 5.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.