Description

n-Acetyl Serotonin B-D-Glucuronide is a key conjugated metabolite of melatonin, formed via the glucuronidation pathway. This compound is of significant interest for researchers investigating the metabolism, pharmacokinetics, and clearance mechanisms of serotonin and melatonin derivatives. It serves as a critical reference standard and analytical reagent for laboratories in the pharmaceutical, clinical diagnostics, and life science research sectors requiring precise quantification of neurohormone metabolites.

Application

• Biomarker Research & Clinical Diagnostics: Used as a certified reference material for the quantitative analysis of melatonin and serotonin metabolites in biological samples (e.g., plasma, urine, cerebrospinal fluid).
• Pharmacokinetic & Metabolism Studies: Essential for studying the metabolic fate, bioavailability, and elimination pathways of melatonin and related neuroactive compounds in preclinical and clinical research.
• Enzyme Activity Assays: Serves as a specific substrate or standard for investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in phase II drug metabolism.
• Pharmaceutical Development: Employed in the development and validation of analytical methods (HPLC, LC-MS/MS) for drug impurity profiling and metabolite identification in new drug applications.
• Neuroscience & Endocrinology Research: A vital tool for elucidating the role of melatonin and serotonin conjugation in circadian rhythm regulation, sleep studies, and neuroendocrine function.
• Quality Control & Standardization: Acts as a high-purity calibration standard to ensure accuracy and reproducibility in analytical laboratories and quality control environments.

Basic Information

Product Name	n-Acetyl Serotonin B-D-Glucuronide
CAS No.	18430-06-3
Molecular Formula	C₁₉H₂₄N₂O₉
Molecular Weight	424.40 g/mol
Synonyms	N-Acetyl-5-hydroxytryptamine glucuronide; N-Acetylserotonin glucuronide; 5-Methoxy-N-acetyltryptamine glucuronide; Melatonin metabolite; 5-Hydroxy-N-acetyltryptamine O-β-D-glucuronide; N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide β-D-glucopyranosiduronic acid; Serotonin glucuronide conjugate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our n-Acetyl Serotonin B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and chromatographic data is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.