Description

Sangivamycin CAS NO 18417-89-5 is a nucleoside antibiotic analog of adenosine, structurally related to toyocamycin. This compound is of significant interest in biochemical and pharmaceutical research due to its potent inhibitory activity against protein kinases, particularly protein kinase C (PKC). It serves as a valuable research tool for studying signal transduction pathways, cell proliferation, and apoptosis. Key industries that utilize this high-purity biochemical include pharmaceutical R&D, academic research institutions, and biotechnology companies focused on oncology and cell biology.

Application

• Biochemical Research: Used as a selective inhibitor of protein kinase C (PKC) and other kinases to study intracellular signaling mechanisms.
• Oncology Research: Investigated for its antiproliferative and pro-apoptotic effects in various cancer cell line studies.
• Cell Biology Studies: Employed to explore the role of PKC in cell differentiation, tumor promotion, and vascular function.
• Pharmaceutical Development: Serves as a lead compound or reference standard in the discovery and development of novel kinase-targeted therapeutics.
• Enzyme Inhibition Assays: Utilized in in vitro assays to characterize kinase activity and screen for new inhibitors.
• Academic Research: A key reagent for graduate and post-doctoral research in molecular pharmacology and medicinal chemistry.

Basic Information

Product Name	Sangivamycin
CAS No.	18417-89-5
Molecular Formula	C12H15N5O5
Molecular Weight	309.28 g/mol
Synonyms	7-Cyano-7-deazaguanosine; NSC 65346; Antibiotic U 12898; Sangivamycin; 4-Amino-5-cyano-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 7-Cyano-7-deazaguanosine; Pyrrolo[2,3-d]pyrimidine nucleoside antibiotic
EINECS	Contact for details

Quality Control

Our Sangivamycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. For long-term storage, keep desiccated. Allow the vial to warm to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Assayed for PKC inhibition

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.