Description

All-Trans 4-Hydroxyretinal is a high-purity, specialized derivative of vitamin A (retinal) featuring a hydroxyl group at the 4-position. This compound is a critical biochemical intermediate and reference standard for research into visual phototransduction and chromophore regeneration. It is essential for scientists and manufacturers in the pharmaceutical, life science research, and nutraceutical sectors who require precise molecular tools for studying retinal proteins and developing related therapies.

Application

• Biochemical Research: As a key chromophore precursor for studying rhodopsin and other visual pigments.
• Reference Standard: For analytical method development and validation in pharmaceutical quality control labs.
• Enzymology Studies: Substrate for investigating the activity of retinal dehydrogenases and isomerases.
• Photobiology: Research on the molecular mechanisms of vision and light-sensitive biological processes.
• Advanced Material Synthesis: Building block for synthesizing novel retinoid analogs with potential therapeutic applications.
• Cell Culture & In-vitro Studies: Component in specialized media for studying retinal cell biology and differentiation.

Basic Information

Product Name	All-Trans 4-Hydroxyretinal
CAS No.	18344-42-8
Molecular Formula	C20H28O2
Molecular Weight	300.44 g/mol
Synonyms	4-Hydroxyretinal; all-trans-4-Hydroxyretinal; Vitamin A Aldehyde, 4-Hydroxy-; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4-hydroxy-2,4,6,8-nonatetraenal; 4-Hydroxyretinaldehyde; Retinal, 4-hydroxy-
EINECS	Contact for details

Quality Control

Our All-Trans 4-Hydroxyretinal is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) documenting purity, isomer content, and other critical parameters are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
All-Trans Isomer Content (HPLC)	≥ 90%
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.