Description

Serotonin β-D-Glucuronide CAS NO 18186-43-1 is a specific glucuronide conjugate of the essential neurotransmitter serotonin, representing a key metabolite in mammalian biochemical pathways. This high-purity reference standard is critical for analytical research, enabling precise quantification and metabolic profiling in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostic developers, and academic researchers focused on neurochemistry, pharmacokinetics, and biomarker discovery.

Application

• Biomarker Research & Clinical Diagnostics: Serves as a crucial reference standard for the accurate quantification of serotonin metabolites in urine, plasma, and cerebrospinal fluid in studies related to carcinoid tumors, depression, and other neurological conditions.
• Pharmaceutical Development & Pharmacokinetics (PK/PD): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the metabolic fate of serotonin and serotonin-related drug candidates, informing dosage and safety profiles.
• Enzymatic & Metabolic Pathway Analysis: Acts as a substrate or standard in assays investigating the activity of UDP-glucuronosyltransferase (UGT) enzymes and the glucuronidation pathway.
• Neurochemical Research: Employed in neuroscience to study serotonin turnover, clearance mechanisms, and the role of conjugation in regulating serotoninergic signaling.
• Quality Control & Method Validation: Essential for developing and validating robust HPLC, LC-MS/MS, and other chromatographic methods in analytical and forensic toxicology laboratories.

Basic Information

Product Name	Serotonin β-D-Glucuronide
CAS No.	18186-43-1
Molecular Formula	C16H20N2O8
Molecular Weight	368.34 g/mol
Synonyms	5-HT-O-β-D-Glucuronide; 5-Hydroxytryptamine O-β-D-glucuronide; Serotonin O-β-D-Glucuronide; 5-HT Glucuronide; Serotonin glucuronide; 3-(2-Aminoethyl)-1H-indol-5-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Serotonin β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) providing batch-specific results is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.