Description

Thebaine is a naturally occurring benzylisoquinoline alkaloid, a key intermediate in the synthesis of numerous pharmaceutical compounds. Its unique chemical structure makes it a critical precursor for the production of essential opioid analgesics and other specialty pharmaceuticals. This high-purity intermediate is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical synthesis facilities engaged in advanced organic chemistry and drug development.

Application

• Pharmaceutical Intermediate: Primary use as a crucial starting material for the semi-synthesis of opioid medications such as oxycodone, naloxone, naltrexone, and buprenorphine.
• Research & Development: Used in academic and industrial R&D for studying opioid receptor pharmacology and developing new analgesic or addiction treatment therapies.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard in quality control laboratories for HPLC, GC-MS, or other chromatographic assays.
• Fine Chemical Synthesis: Employed as a building block in the multi-step synthesis of complex organic molecules and other specialized alkaloid derivatives.
• Controlled Substance Manufacturing: Supplied to licensed facilities for the authorized production of Schedule II controlled substances under strict regulatory oversight (e.g., DEA, EMA).

Basic Information

Product Name	Thebaine
CAS No.	18161-81-4
Molecular Formula	C19H21NO3
Molecular Weight	311.38 g/mol
Synonyms	Paramorphine; 3,6-Dimethoxy-17-methyl-4,5-epoxy-6,8,14-morphinatriene; Thebain; Thebaïn; Thebaïne; Thebaine alkaloid; 6,8-Didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
EINECS	242-045-4

Quality Control

Our Thebaine is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We adhere to relevant cGMP guidelines where applicable to support our clients' regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.