Description

Androsta-3,5-Diene-3,17α-Diol Bis(Heptafluorobutyrate) is a high-purity, fluorinated steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the development of novel therapeutic agents and diagnostic tools. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in steroid chemistry, metabolic studies, and the synthesis of specialized bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Analytical Reference Standard: Used for method development, calibration, and quality control in analytical laboratories employing techniques like HPLC, LC-MS, and GC-MS for steroid analysis.
• Biochemical Research: Employed in metabolic pathway studies, enzyme inhibition assays, and receptor binding studies to investigate steroid hormone action and metabolism.
• Chemical Derivatization Agent: The heptafluorobutyrate groups make it useful for enhancing detection sensitivity in gas chromatography (GC) applications for trace steroid analysis.
• Process Development: Serves as a model compound or intermediate during the scale-up and optimization of steroid manufacturing processes under GMP conditions.

Basic Information

Product Name	Androsta-3,5-Diene-3,17α-Diol Bis(Heptafluorobutyrate)
CAS No.	18072-22-5
Molecular Formula	C27H28F14O4
Molecular Weight	682.50 g/mol
Synonyms	3β,17β-Dihydroxyandrosta-3,5-diene 3,17-Bis(heptafluorobutyrate); Androsta-3,5-diene-3β,17β-diol Diheptafluorobutyrate; 3,17-Diheptafluorobutyryloxy-androsta-3,5-diene; 3β,17β-Bis(heptafluorobutyryloxy)androsta-3,5-diene; Androstadienediol DiHFB; Androstadienediol Bis(HFB); Androstadienediol Diheptafluorobutyrate; 3β,17β-Dihydroxy-δ3,5-androstadiene 3,17-Diheptafluorobutyrate
EINECS	Contact for details

Quality Control

Our Androsta-3,5-Diene-3,17α-Diol Bis(Heptafluorobutyrate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established release criteria.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.