Description

3-(2-Bromoacetamido)-2,2,5,5-Tetramethyl-1-Pyrrolidinoxy is a stable nitroxide spin label derivative, widely recognized by its CAS number 17932-40-0. This compound is a critical reagent for site-directed spin labeling (SDSL) in electron paramagnetic resonance (EPR) spectroscopy, enabling the study of protein dynamics, structure, and conformational changes. It is essential for researchers and manufacturers in the fields of structural biology, biophysics, and pharmaceutical development who require precise molecular probes.

Application

• Site-Directed Spin Labeling (SDSL): Primary reagent for covalently attaching a spin label to specific cysteine residues in proteins for EPR studies.
• Protein Dynamics & Conformational Analysis: Used to investigate protein folding, unfolding, and real-time structural changes.
• Membrane Protein Studies: Essential tool for probing the structure and environment of challenging membrane-bound proteins.
• Drug Discovery & Development: Employed in studying protein-ligand interactions and the mechanistic action of potential therapeutics.
• Nucleic Acid Research: Can be adapted for spin-labeling nucleic acids to study their structure and protein-nucleic acid complexes.
• Material Science: Used as a stable radical in the development of advanced polymers and functional materials.

Basic Information

Product Name	3-(2-Bromoacetamido)-2,2,5,5-Tetramethyl-1-Pyrrolidinoxy
CAS No.	17932-40-0
Molecular Formula	C10H18BrN2O2
Molecular Weight	278.17 g/mol
Synonyms	3-(2-Bromoacetamido)-PROXYL; 3-(Bromoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; Bromoacetamido-PROXYL; 3-Bromoacetamido-PROXYL; 2,2,5,5-Tetramethyl-1-pyrrolidinyloxy-3-bromoacetamide; 3-(Bromoacetamido)-PROXYL spin label; 1-Oxyl-2,2,5,5-tetramethyl-δ3-pyrroline-3-bromoacetamide; PROXYL bromoacetamide
EINECS	Contact for details

Quality Control

Our 3-(2-Bromoacetamido)-2,2,5,5-Tetramethyl-1-Pyrrolidinoxy is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
EPR Analysis	Single major radical species
Melting Point	Contact for details
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.