Description

(R,S)-Norcotinine CAS NO 17708-87-1 is a high-purity reference standard and key intermediate in pharmaceutical research and development. This compound is of significant value for its role in metabolic and pharmacokinetic studies related to nicotine and its analogs. It is primarily required by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in analytical method development, biomarker research, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments and validation of methods in HPLC, LC-MS, and GC-MS analysis.
• Metabolite Research: Serves as a critical metabolite standard in studies investigating the biotransformation and pharmacokinetics of nicotine and related alkaloids.
• Biochemical Research: Employed as a reagent in enzymatic assays and receptor binding studies to understand nicotinic acetylcholine receptor (nAChR) interactions and signaling pathways.
• Organic Synthesis Intermediate: Acts as a versatile chiral building block for the synthesis of more complex molecules in medicinal chemistry programs.
• Forensic & Toxicological Analysis: Utilized as an analytical standard in forensic laboratories for the precise identification and quantification of nicotine metabolites in biological samples.
• Diagnostic Kit Development: Incorporated into the development of immunoassays and diagnostic kits for monitoring tobacco use exposure and related health studies.

Basic Information

Product Name	(R,S)-Norcotinine
CAS No.	17708-87-1
Molecular Formula	C9H12N2O
Molecular Weight	164.21 g/mol
Synonyms	Norcotinine; (Rac)-Norcotinine; DL-Norcotinine; 2-Pyridinepropanoic acid, 1-methyl-5-(3-oxo-3-pyridinyl)-, methyl ester; 1-Methyl-5-(3-oxo-3-pyridinyl)-2-pyrrolidinone; Nicotine metabolite N'-oxide (related); Cotinine N-oxide (reduced form); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (R,S)-Norcotinine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the contents from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.