Description

p-Tolyl-β-D-Glucuronide is a high-purity biochemical reagent widely used as a reference standard and substrate in enzymatic and analytical research. This compound is critical for ensuring accuracy and reliability in assays that measure glucuronidase activity, a key enzyme in drug metabolism and detoxification pathways. It is primarily needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting studies in biochemistry, pharmacology, and toxicology.

Application

• Enzyme Substrate: Used as a specific chromogenic or fluorogenic substrate for β-glucuronidase enzyme activity assays in diagnostic and research applications.
• Reference Standard: Serves as a primary analytical standard for the quantification of glucuronide metabolites in pharmaceutical development and bioanalytical studies.
• Biochemical Research: Employed in studies of drug metabolism, specifically in Phase II glucuronidation pathways, to understand pharmacokinetics and detoxification mechanisms.
• Diagnostic Reagent: A key component in clinical diagnostic kits for detecting bacterial contamination (e.g., E. coli) via β-glucuronidase markers.
• Toxicology Studies: Utilized in in vitro and in vivo models to investigate the biotransformation and elimination of xenobiotics.
• Pharmaceutical QC: Applied in quality control testing of enzyme preparations and in validating analytical methods for metabolite identification.

Basic Information

Product Name	p-Tolyl-β-D-Glucuronide
CAS No.	17680-99-8
Molecular Formula	C₁₃H₁₆O₈
Molecular Weight	300.26 g/mol
Synonyms	4-Methylphenyl β-D-Glucopyranosiduronic Acid; p-Cresyl β-D-Glucuronide; 4-Methylphenyl β-D-Glucuronide; p-Tolyl β-D-Glucopyranosiduronic Acid; β-D-Glucopyranosiduronic Acid, 4-Methylphenyl; p-Cresol Glucuronide; Glucuronide p-Tolyl Ester; 17680-99-8
EINECS	Contact for details

Quality Control

Our p-Tolyl-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.