Description

2'-Deoxy-6-Thioguanosine 5'-Triphosphate is a modified nucleoside triphosphate analog, a critical building block for advanced molecular biology and biochemistry research. Its core value lies in its ability to act as a substrate for DNA polymerases, enabling the site-specific incorporation of a thiolated base for applications like cross-linking, labeling, and structural studies. This high-purity biochemical is essential for researchers and developers in pharmaceutical discovery, diagnostic assay development, and next-generation sequencing technologies.

Application

• DNA Sequencing & Synthesis: Used as a modified nucleotide triphosphate (dNTP) in enzymatic DNA synthesis and sequencing-by-synthesis platforms.
• Site-Specific Labeling & Cross-linking: The thiol group enables covalent attachment of fluorophores, biotin, or other probes, or can form disulfide bonds for structural stabilization.
• Antiviral & Anticancer Research: Serves as a precursor or analog in the study of nucleoside-based therapeutics targeting viral polymerases or cellular DNA replication.
• SELEX (Systematic Evolution of Ligands by Exponential Enrichment): Incorporated into DNA libraries to create aptamers with enhanced stability or novel functional properties.
• Structural Biology: Facilitates the preparation of modified DNA or RNA oligonucleotides for X-ray crystallography, NMR, and cryo-EM studies.
• Diagnostic Probe Development: Utilized in the creation of highly specific and sensitive detection probes for PCR-based assays and biosensors.

Basic Information

Product Name	2'-Deoxy-6-Thioguanosine 5'-Triphosphate
CAS No.	17660-38-7
Molecular Formula	C10H16N5O13P3S
Molecular Weight	539.22 g/mol
Synonyms	6-Thio-dGTP; 2'-Deoxy-6-thioguanosine-5'-triphosphate; 6-Thioguanine deoxyriboside triphosphate; d(s6G)TP; 6-Thio-2'-deoxyguanosine-5'-triphosphate; Deoxy-6-thioguanosine triphosphate; 6-Thio-dGTP sodium salt (common salt form); 6-Thioguanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-6-Thioguanosine 5'-Triphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and spectroscopy, are validated to provide reliable specifications for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg (if applicable)
Biological Activity	Functional in polymerase assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.