Description

Tetrahydrobiopterin (BH4) is a critical enzymatic cofactor essential for the synthesis of key neurotransmitters and nitric oxide. Its primary commercial value lies in its role as a therapeutic agent and a high-purity biochemical reagent for research and pharmaceutical development. This compound is vital for manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors, particularly those focused on metabolic disorders, cardiovascular research, and neurological studies.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of treatments for metabolic disorders such as phenylketonuria (PKU) and other BH4 deficiency-related conditions.
• Biochemical Research: Essential cofactor for studying enzyme kinetics of phenylalanine hydroxylase, tyrosine hydroxylase, and nitric oxide synthase.
• Diagnostic Reagent: Used in clinical diagnostic kits and assays to measure enzyme activity or metabolite levels in blood and tissue samples.
• Cell Culture & Neuroscience: Supplement in cell culture media to support the growth and function of neuronal cells and study neurotransmitter synthesis pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing and regulatory testing.

Basic Information

Product Name	Tetrahydrobiopterin
CAS No.	17528-72-2
Molecular Formula	C9H15N5O3
Molecular Weight	241.25 g/mol
Synonyms	BH4; (6R)-5,6,7,8-Tetrahydrobiopterin; 6R-BH4; Sapropterin; 2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one; 6R-5,6,7,8-Tetrahydro-L-biopterin; Kuvan (brand name active ingredient)
EINECS	Contact for details

Quality Control

Our Tetrahydrobiopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical and research use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range upon request
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Microbial Limits	Meets standard for biochemicals

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.