Description

Bilirubin Di-Acyl-B-D-Glucuronide is a key conjugated metabolite of bilirubin, essential for understanding hepatic metabolism and detoxification pathways. This high-purity reference standard is critical for ensuring analytical accuracy in research and diagnostic development. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostics manufacturers, and academic institutions focused on liver function, jaundice, and metabolic disorder studies.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for the calibration and validation of analytical methods (HPLC, LC-MS) used in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Diagnostics Development: Essential for developing and quality controlling in-vitro diagnostic (IVD) assays that measure conjugated bilirubin levels to assess liver function and diagnose hepatobiliary disorders.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of UDP-glucuronosyltransferases (UGTs) and other conjugation enzymes.
• Toxicology Studies: Employed in research models to study bilirubin metabolism, hyperbilirubinemia (jaundice), and the efficacy of potential therapeutic agents.
• Quality Control Material: Acts as a certified reference material (CRM) for ensuring the accuracy and traceability of bilirubin measurements in commercial diagnostic kits and laboratory services.

Basic Information

Product Name	Bilirubin Di-Acyl-B-D-Glucuronide
CAS No.	17459-92-6
Molecular Formula	C₄₅H₅₂N₄O₁₈
Molecular Weight	936.92 g/mol
Synonyms	Bilirubin Ditaurate; Bilirubin Diglucuronide; Ditaurobilirubin; Conjugated Bilirubin; Delta Bilirubin; Bilirubin-IXα bis(β-D-glucopyranosiduronic acid); Biliatris; 1,19-Dioxo-3,18-bis[(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,17-bis(2-carboxyethyl)-10,23-dihydro-5H,14H,15H-dipyrrolo[2,3-a:2',3'-h]porphine-2,16-dipropanoic acid
EINECS	Contact for details

Quality Control

Our Bilirubin Di-Acyl-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol (with base)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.