Description

Dimethylsphinganine (D18:0) is a fully saturated, dimethylated sphingoid base, a key intermediate and reference standard in sphingolipid research. This compound is essential for studying sphingolipid metabolism, cell signaling pathways, and membrane biology. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and analytical chemistry sectors for use as a critical biochemical tool and a high-purity calibration standard.

Application

• Biochemical Research Standard: Serves as a high-purity analytical reference standard for mass spectrometry (MS), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC) in lipidomics studies.
• Sphingolipid Metabolism Studies: Used as a precursor or intermediate in enzymatic assays and metabolic pathway research to investigate ceramide and complex sphingolipid synthesis.
• Cell Signaling Research: Employed in studies exploring the role of sphingoid bases and their derivatives in apoptosis, cell proliferation, and stress responses.
• Pharmaceutical Development: Acts as a building block or reference compound in the discovery and development of therapeutics targeting sphingolipid-related disorders.
• Membrane Biophysics: Utilized in model membrane systems to study the influence of saturated sphingoid bases on membrane structure, fluidity, and domain formation.

Basic Information

Product Name	Dimethylsphinganine (D18:0)
CAS No.	17267-46-8
Molecular Formula	C₂₀H₄₃NO₂
Molecular Weight	329.57 g/mol
Synonyms	D-erythro-Dihydrosphingosine, D18:0 Dihydro Sphingosine; N,N-Dimethylsphinganine; (2S,3R)-2-(Dimethylamino)-1,3-octadecanediol; Dihydro-N,N-dimethylsphingosine; D-erythro-C18-Dihydrosphingosine, dimethyl derivative; N,N-Dimethyldihydrosphingosine; DMS
EINECS	Contact for details

Quality Control

Our Dimethylsphinganine (D18:0) is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, MS, and NMR, are validated to provide reliable data for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.