Description

7-Hydroxyguanine is a significant oxidized derivative of guanine, a key nucleobase in DNA and RNA. This compound is of critical importance in biochemical research as a biomarker for oxidative stress and DNA damage studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on understanding cellular oxidative processes, mutagenesis, and aging.

Application

• Biomarker Research: Used as a standard and reference material in the study of oxidative DNA damage and repair mechanisms.
• Pharmaceutical Development: Employed in screening assays to evaluate the efficacy of novel antioxidant and chemopreventive drug candidates.
• Diagnostic Assays: Serves as a critical component in the development and calibration of diagnostic kits for measuring oxidative stress levels in biological samples.
• Toxicology Studies: Applied in research to assess the genotoxic impact of environmental toxins, radiation, and pharmaceutical compounds.
• Academic Research: Fundamental tool in universities and research institutes for investigations into cancer biology, neurodegenerative diseases, and the biochemistry of aging.
• Quality Control Standards: Used as a certified reference material (CRM) in analytical laboratories to ensure accuracy in chromatographic and mass spectrometric analyses of nucleic acid modifications.

Basic Information

Product Name	7-Hydroxyguanine
CAS No.	16870-91-0
Molecular Formula	C5H5N5O2
Molecular Weight	167.13 g/mol
Synonyms	7-Hydroxyguanine; 2-Amino-7,9-dihydro-1H-purin-6-one; 7-OH-Gua; 7-Hydroxy-2-aminopurine-6(1H)-one; Guan-7-ol; 7-HG; Oxidized Guanine Derivative; 7-Hydroxy-2-aminohypoxanthine
EINECS	240-904-5

Quality Control

Our 7-Hydroxyguanine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to GMP-aligned practices for laboratory chemicals, and our analytical methods, including HPLC and MS, are validated to provide reliable data for critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.