Description

Demethyleneberberine Chloride is a high-purity, semi-synthetic derivative of the natural alkaloid berberine. This compound is valued for its enhanced bioavailability and potent biological activity compared to its parent molecule. It is primarily utilized in the pharmaceutical and nutraceutical industries for research and development of therapeutic agents targeting metabolic and inflammatory pathways. Our supply of Demethyleneberberine Chloride CAS NO 16705-03-6 ensures consistent quality for critical applications.

Application

• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel small-molecule drugs.
• Nutraceutical Formulations: Incorporated into dietary supplements for metabolic health support.
• Biochemical Research: Used as a reference standard and active agent in pharmacological and metabolic studies.
• Preclinical Development: Employed in animal model studies to investigate efficacy and mechanisms of action.
• Active Pharmaceutical Ingredient (API): Potential use in the manufacture of finished dosage forms.
• Life Science Reagents: Supplied to laboratories for cell-based assays and signaling pathway analysis.

Basic Information

Product Name	Demethyleneberberine Chloride
CAS No.	16705-03-6
Molecular Formula	C19H16ClNO4
Molecular Weight	357.79 g/mol
Synonyms	8,13-Didehydro-3,9-dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride; Demethyleneberberine HCl; NSC 354731; 13-Methylberberine chloride derivative; Berberine, demethylene-, chloride
EINECS	Contact for details

Quality Control

Our Demethyleneberberine Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.