Description

9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of potent topical corticosteroids, enabling precise control over pharmacological activity and bioavailability. This compound is essential for pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on dermatological and anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a key precursor in the multi-step synthesis of high-potency topical corticosteroids like Halobetasol Propionate.
• Research & Development: Critical for medicinal chemistry programs exploring new steroid-based drug candidates with modified potency and metabolic profiles.
• Process Chemistry: Used in scale-up and optimization of API manufacturing processes under current Good Manufacturing Practice (cGMP) standards.
• Reference Standard: Serves as an analytical standard for quality control and impurity profiling in steroid API production.
• Dermatological API Synthesis: Integral to the production chain of APIs used in creams, ointments, and lotions for treating psoriasis, eczema, and dermatitis.

Basic Information

Product Name	9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate
CAS No.	16154-10-2
Molecular Formula	C₂₈H₃₇ClO₆
Molecular Weight	505.05 g/mol
Synonyms	Halobetasol Propionate Intermediate; 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate (related); 9-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-valerate; U-63033 (Potential research code); 17-Valerate ester of 9-Chloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 16β-Methyl-9-chloro-δ¹,⁴-pregnadiene-11β,17α-diol-3,20-dione 17-valerate
EINECS	Contact for details

Quality Control

Our 9-Chloro-11Beta,17-Dihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and cGMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.