Description

Desthiobiotin is a key intermediate and analog of D-biotin, distinguished by the absence of the sulfur atom in the tetrahydrothiophene ring. This compound is of significant value in biochemical research and pharmaceutical development due to its role in studying biotin metabolism and its utility as a precursor in synthesis. It is primarily sought by professionals in the life sciences, pharmaceutical manufacturing, and fine chemical synthesis sectors for applications in assay development, metabolic pathway research, and the production of specialized biochemicals.

Application

• Biochemical Research: Used as a critical tool compound for studying biotin-avidin binding interactions, biotin transport mechanisms, and enzymatic processes involving biotin-dependent carboxylases.
• Pharmaceutical Intermediate: Serves as a vital building block in the synthesis of novel biotin-labeled compounds, prodrugs, and active pharmaceutical ingredients (APIs) targeting metabolic disorders.
• Diagnostic Reagent Production: Employed in the manufacturing of components for diagnostic kits and assays that utilize biotin-streptavidin technology for signal amplification.
• Nutritional Science Studies: Acts as a reference standard or experimental compound in research investigating vitamin B7 (biotin) analogs and their biological activity.
• Cell Culture & Microbiology: Utilized in defined media formulations for studying bacterial and eukaryotic cell growth under controlled biotin-related conditions.

Basic Information

Product Name	Desthiobiotin
CAS No.	15720-25-9
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	D-Desthiobiotin; (+)-Desthiobiotin; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric Acid (desthio analog); Biotin Desthio; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic Acid (desthio); Vitamin H Desthio Analog; NSC 75947
EINECS	239-826-4

Quality Control

Our Desthiobiotin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to support regulatory filings for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	+45.0° to +50.0° (c=1 in 0.1N NaOH)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.