Description

1,3,5[10]-Estratriene-3,17Beta-Diol 17-Glucuronide Sodium Salt is a high-purity conjugated metabolite of estradiol, specifically the 17β-glucuronide sodium salt. This compound is of critical importance as a reference standard and key intermediate in analytical and diagnostic applications, ensuring accurate quantification and method validation. It is primarily required by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and contract research organizations (CROs) engaged in hormone metabolism studies, clinical testing, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, LC-MS/MS) in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Diagnostics: Serves as a critical calibrator or control in immunoassays and mass spectrometry-based tests for measuring estrogen metabolites in patient samples.
• Biochemical Research: Employed in studies investigating estrogen conjugation pathways, enzyme activity (e.g., UGTs), and metabolic profiling.
• Quality Control: Acts as an impurity marker or system suitability standard in the quality control of steroid-based pharmaceutical products.
• Toxicology Studies: Utilized in research examining the excretion profiles and bio-monitoring of endogenous and exogenous estrogens.

Basic Information

Product Name	1,3,5[10]-Estratriene-3,17Beta-Diol 17-Glucuronide Sodium Salt
CAS No.	15087-02-2
Molecular Formula	C24H31O8Na
Molecular Weight	470.49 g/mol
Synonyms	Estradiol 17β-D-Glucuronide Sodium Salt; 17β-Estradiol 17-Glucuronide Sodium Salt; E2-17G Sodium Salt; Sodium Estradiol 17-Glucuronide; NSC 113492; 3,17β-Dihydroxyestra-1,3,5(10)-trien-17-yl β-D-Glucopyranosiduronic Acid Sodium Salt; Estra-1,3,5(10)-triene-3,17β-diol 17-glucuronide sodium salt
EINECS	Contact for details

Quality Control

Our 1,3,5[10]-Estratriene-3,17Beta-Diol 17-Glucuronide Sodium Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical applications. All batches undergo rigorous quality testing, including chromatographic purity assays and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and analytical methods (e.g., HPLC, NMR) is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.