Description

Estradiol-3-Glucuronide is a major, water-soluble metabolite of the endogenous estrogen, estradiol. This compound is of significant value as a high-purity reference standard and a critical biomarker in clinical and research settings. It is primarily needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting endocrinology and metabolism studies.

Application

• Biomarker & Diagnostic Standard: Used as a primary calibrator and control in immunoassays and LC-MS/MS methods for quantifying estrogen metabolites in biological samples (serum, urine).
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control in the development and production of hormone-based therapeutics.
• Metabolic Pathway Research: Essential for studying Phase II conjugation (glucuronidation) pathways, enzyme kinetics (UGT activity), and estrogen metabolism in pharmacological and toxicological research.
• Clinical Study Support: Utilized in clinical trials to monitor patient hormone levels, assess drug interactions affecting estrogen metabolism, and investigate endocrine-related conditions.

Basic Information

Product Name	Estradiol-3-Glucuronide
CAS No.	15270-30-1
Molecular Formula	C24H32O8
Molecular Weight	448.51 g/mol
Synonyms	Estrone 3-Glucuronide; 17β-Estradiol 3-Glucuronide; Estradiol 3-β-D-Glucuronide; E2-3G; Estradiol 3-G; 3-Hydroxyestra-1,3,5(10)-trien-17β-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our Estradiol-3-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) with lot-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.