Description

17β-Estradiol 3-o-Benzyl 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester) is a key synthetic intermediate and reference standard in the production and analytical validation of steroid metabolites and hormone conjugates. This compound is critical for researchers and manufacturers requiring high-purity building blocks for pharmaceutical development and advanced biochemical studies. It is primarily utilized in the synthesis of estradiol glucuronide derivatives, which are essential for diagnostic applications, metabolic research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthetic pathway for steroid-based active pharmaceutical ingredients (APIs) and hormone therapies.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of estradiol metabolites in clinical and forensic toxicology.
• Biochemical Research: Serves as a substrate or standard in studies of steroid metabolism, conjugation pathways (glucuronidation), and enzyme activity assays.
• Diagnostic Reagent Manufacturing: Employed in the production of calibrators, controls, and antibodies for immunoassays measuring hormone levels.
• Metabolite Synthesis: Used to synthesize specific glucuronidated metabolites of 17β-estradiol for pharmacokinetic and pharmacodynamic studies.

Basic Information

Product Name	17β-Estradiol 3-o-Benzyl 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester)
CAS No.	14364-98-8
Molecular Formula	C₃₇H₄₆O₁₂
Molecular Weight	682.76 g/mol
Synonyms	Estradiol 3-Benzyl Ether 17β-Glucuronide Methyl Ester Triacetate; 17β-Estradiol 3-Benzyl-17-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronic Acid) Methyl Ester; Estr-1,3,5(10)-triene-3,17β-diol 3-(phenylmethyl) Ether 17β-[(2,3,4-Tri-O-acetyl-β-D-glucopyranosyl)oxy] Methyl Ester; 17β-Estradiol 3-Benzyl Ether Glucuronide Triacetate Methyl Ester; Estradiol Glucuronide Derivative; 3-Benzylestradiol 17-(Triacetylglucuronide) Methyl Ester
EINECS	Contact for details

Quality Control

Our 17β-Estradiol 3-o-Benzyl 17-(2,3,4-Tri-o-Acetyl-β-D-Glucuronide Methyl Ester) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.