Description

Glyoxal Bis(Guanylhydrazone) is a polyamine analog and a potent inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the polyamine biosynthesis pathway. This compound is of significant interest in biochemical and pharmaceutical research for its ability to modulate cellular polyamine levels, which are critical for cell growth and proliferation. It serves as a valuable research chemical for scientists in oncology, molecular biology, and enzymology studying cell cycle regulation, apoptosis, and potential therapeutic interventions.

Application

• Biochemical Research: Used as a specific inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC) to study polyamine metabolism and its role in cellular processes.
• Oncology Research: Investigated for its antiproliferative effects in cancer cell studies, exploring mechanisms of polyamine depletion on tumor growth.
• Enzymology Studies: Employed to characterize the kinetics and inhibition of AdoMetDC in purified enzyme assays.
• Cell Biology: Utilized to manipulate intracellular polyamine pools to understand their function in differentiation, apoptosis, and cell cycle progression.
• Pharmaceutical Development: Serves as a reference compound or lead structure in the discovery of novel polyamine-based therapeutics.
• Academic Research: A key reagent for universities and research institutes conducting fundamental research on polyamine biology.

Basic Information

Product Name	Glyoxal Bis(Guanylhydrazone)
CAS No.	14358-42-0
Molecular Formula	C6H14N10
Molecular Weight	226.25 g/mol
Synonyms	GBG; Glyoxal Bis(guanylhydrazone); NSC-32946; 1,1'-[1,2-Ethanediylbis(oxy-2,1-ethanediyl)]bis[3-(4-aminophenyl)urea]; Bis(guanylhydrazone) of glyoxal; AdoMetDC Inhibitor GBG; S-Adenosylmethionine Decarboxylase Inhibitor
EINECS	Contact for details

Quality Control

Our Glyoxal Bis(Guanylhydrazone) is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.