Description

H-D-Phe-Pna CAS NO 14235-18-8 is a high-purity, protected amino acid derivative specifically designed for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide sequences with defined stereochemistry. It is an essential raw material for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers focused on creating novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of phenylalanine residues in automated and manual peptide assembly.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs targeting metabolic disorders, oncology, and neurological conditions.
• Bioconjugation and Labeling: The reactive para-nitroanilide (Pna) group facilitates its use in creating peptide conjugates for diagnostic assays and targeted delivery systems.
• Enzyme Substrate Synthesis: Employed in the preparation of specific chromogenic and fluorogenic substrates for protease and peptidase activity assays.
• Chemical Biology & Proteomics: A valuable tool for studying enzyme mechanisms, protein-protein interactions, and cellular signaling pathways.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	H-D-Phe-Pna
CAS No.	14235-18-8
Molecular Formula	C₁₅H₁₅N₃O₃
Molecular Weight	285.30 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-phenylalanine 4-nitroanilide; Boc-D-Phe-pNA; Boc-D-Phenylalanine p-nitroanilide; D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitroanilide; (R)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid 4-nitroanilide; BOC-D-PHE-PNA; H-D-Phe-pNA; Peptide Synthesis Building Block BOC-D-Phe-PNA
EINECS	Contact for details

Quality Control

Every batch of H-D-Phe-Pna is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications for identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from HPLC, NMR, and optical rotation analyses to guarantee batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.