Description

Hydroxymethyldeoxyuridine Triphosphate is a modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and development. Its primary value lies in its role as a substrate for DNA polymerases, enabling the study of DNA replication, repair mechanisms, and the development of novel diagnostic and therapeutic agents. This high-purity biochemical is essential for researchers and developers in the fields of molecular biology, enzymology, and pharmaceutical discovery.

Application

• Enzymology Studies: Used as a specialized substrate to investigate the kinetics and fidelity of DNA polymerases and other nucleic acid-processing enzymes.
• Molecular Biology Research: Incorporated into oligonucleotide synthesis for creating probes and primers with specific modified bases for advanced genomic studies.
• Antiviral Drug Development: Serves as a key intermediate or model compound in the research and development of nucleoside analog-based antiviral therapies.
• Diagnostic Assay Development: Employed in the creation of sensitive detection kits, such as those for viral load quantification or mutation analysis.
• Biochemical Synthesis: Acts as a precursor in the enzymatic or chemical synthesis of more complex modified nucleotides and nucleic acids.

Basic Information

Product Name	Hydroxymethyldeoxyuridine Triphosphate
CAS No.	14167-70-5
Molecular Formula	C11H17N2O15P3
Molecular Weight	534.17 g/mol
Synonyms	5-Hydroxymethyldeoxyuridine Triphosphate; 5-Hydroxymethyl-2'-deoxyuridine 5'-triphosphate; 5-Hydroxymethyl-dUTP; HMdUTP; 5-Hydroxymethyl-2'-deoxyuridine-5'-triphosphate; (2R,3S,5R)-5-(4-Hydroxy-5-(hydroxymethyl)-2-oxopyrimidin-1(2H)-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl trihydrogen triphosphate
EINECS	Contact for details

Quality Control

Our Hydroxymethyldeoxyuridine Triphosphate is manufactured under stringent quality systems to ensure the highest standards of purity and consistency required for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and mass spectrometry. We adhere to cGMP principles for the production of research-grade biochemicals, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 3.0%
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.