Description

D-[5-3H]Glucose is a high-specific-activity, tritium-labeled isotopologue of D-glucose, a fundamental biochemical used for tracing metabolic pathways. This labeled compound is essential for sensitive, quantitative research in biochemistry and pharmacology, where precise tracking of glucose uptake and metabolism is required. It is primarily utilized by research scientists and pharmaceutical developers in metabolic studies, drug discovery, and diagnostic assay development.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study glucose uptake, glycolysis, and the pentose phosphate pathway in cell cultures and tissue samples.
• Drug Discovery & Pharmacology: Employed in high-throughput screening assays to evaluate the effects of new drug candidates on cellular glucose metabolism and insulin signaling.
• Diagnostic Research: Serves as a key reagent in the development of in vitro diagnostic tests for metabolic disorders like diabetes.
• Biochemical Research: Fundamental tool for enzymatic studies, membrane transport research, and investigating metabolic flux analysis (MFA).
• Neuroscience Studies: Applied in research on brain energy metabolism, neuronal activity, and neurodegenerative diseases.
• Cancer Research: Used to investigate the altered glucose metabolism (Warburg effect) in various cancer cell lines and tumors.

Basic Information

Product Name	D-[5-3H]Glucose
CAS No.	14049-06-0
Molecular Formula	C6H113HO6
Molecular Weight	~183.2 g/mol (based on specific activity)
Synonyms	D-Glucose-5-t; (5-3H)-D-Glucose; 5-Tritio-D-glucose; D-Glucose (5-tritiated); Tritiated D-glucose; [5-3H]Glucose; Glucose-5-t; D-Glucose, 5-tritio-
EINECS	Contact for details

Quality Control

Every batch of D-[5-3H]Glucose is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Radiochemical purity is determined by HPLC and confirmed by TLC. Certificates of Analysis (COA) detailing specific activity, purity, solvent composition, and analytical methods are provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, keep the original container in a secondary containment.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC/TLC)	Conforms to reference standard
Specific Activity	10-40 Ci/mmol (typical range)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water solution (specified ratio)
Concentration	1 mCi/mL (nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.