Description

2-Deoxy-D-Glucose (CAS NO 13299-15-5) is a glucose analog where the 2-hydroxyl group is replaced by hydrogen, making it a critical tool for studying cellular glucose metabolism and glycolysis inhibition. This compound is valued for its ability to competitively inhibit hexokinase, the first enzyme in the glycolytic pathway, leading to energy depletion in cells. It is primarily sought by researchers and manufacturers in the life sciences, pharmaceutical development, and biochemical research sectors for applications in metabolic studies, oncology research, and as a potential therapeutic agent.

Application

• Biochemical Research: A fundamental tool for studying glycolysis, glucose uptake, and energy metabolism in cell cultures and model organisms.
• Oncology & Cancer Research: Investigated for its potential to target cancer cell metabolism, as many tumors exhibit heightened glycolytic activity (the Warburg effect).
• Antiviral Research: Used in studies exploring its ability to inhibit viral replication by disrupting N-linked glycosylation processes in the endoplasmic reticulum.
• Neurobiology: Applied in research on brain energy metabolism, ischemia, and neurodegenerative diseases.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex bioactive molecules and glycoconjugates.
• Metabolic Disorder Studies: Utilized in research models for diabetes and other conditions related to glucose utilization.

Basic Information

Product Name	2-Deoxy-D-Glucose
CAS No.	13299-15-5
Molecular Formula	C6H12O5
Molecular Weight	164.16 g/mol
Synonyms	2-Deoxy-D-arabino-hexose; 2-Deoxyglucose; 2-DG; D-2-Deoxyglucose; 2-Desoxy-D-glucose; D-Arabino-2-deoxyhexose; 2-Deoxy-D-mannose (obsolete); NSC 15193; Glycolysis Inhibitor I
EINECS	236-353-1

Quality Control

Our 2-Deoxy-D-Glucose is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, and a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for every batch upon request. Our quality standards are designed to meet the rigorous demands of pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Specific Optical Rotation	-40° to -48° (c=1 in H2O)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.