Description

Senecionine n-Oxide is a pyrrolizidine alkaloid derivative, a compound of significant interest in biochemical and pharmaceutical research. Its primary value lies in its role as a key intermediate and reference standard for studying the metabolism, toxicity, and potential bioactivity of related alkaloids. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, toxicology, and natural product chemistry sectors who require reliable, well-characterized materials for analytical and developmental work.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of pyrrolizidine alkaloids and their metabolites in drug development and quality control.
• Metabolic Pathway Research: Serves as a critical intermediate in studies investigating the biotransformation and detoxification pathways of hepatotoxic alkaloids.
• Toxicological Studies: Employed in research to understand the structure-activity relationships and mechanisms of toxicity associated with pyrrolizidine alkaloid exposure.
• Analytical Chemistry: Utilized as a high-purity calibrant in advanced analytical techniques such as HPLC, LC-MS, and NMR for method development and validation.
• Natural Product Synthesis: Acts as a building block or precursor in the semi-synthesis of complex alkaloids for biological evaluation.
• Herbal Medicine Safety Assessment: A vital component in assays designed to screen and quantify potentially toxic pyrrolizidine alkaloids in botanical extracts and herbal products.

Basic Information

Product Name	Senecionine n-Oxide
CAS No.	13268-67-2
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	Senecionine N-Oxide; Senecionine 1-Oxide; 12,18-Didehydrosenecionan-11,16-dione, 1-oxide; (13Z)-Senecionan-11,16-dione, 1-oxide; Retrorsine N-oxide (related analog); Pyrrolizidine alkaloid N-oxide; PA N-oxide; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of Senecionine n-Oxide is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chromatographic purity assays and spectroscopic identification, to meet the exacting standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.