Description

n-Hexadecanoyl-D-Sphingosine-1-Phosphocholine is a high-purity, synthetic sphingolipid derivative, specifically a palmitoylated sphingosylphosphorylcholine. This compound is a critical biochemical tool and a key intermediate in the study of cellular signaling pathways, particularly those involving sphingomyelin metabolism and ceramide-mediated processes. It is essential for researchers and manufacturers in advanced life sciences, pharmaceutical development, and diagnostic reagent formulation who require well-defined, high-quality lipid standards and building blocks.

Application

• Biochemical Research & Standard: Used as a high-purity reference standard in mass spectrometry (MS), liquid chromatography (LC), and nuclear magnetic resonance (NMR) for the quantification and identification of sphingolipids in biological samples.
• Lipidomics & Metabolomics: A vital component in lipidomic studies to understand lipid profiles, cell membrane dynamics, and their roles in disease states such as cancer, neurodegeneration, and metabolic disorders.
• Pharmaceutical Development: Serves as a key intermediate or starting material in the synthesis of novel therapeutic agents targeting sphingolipid-related pathways, including enzyme inhibitors and receptor modulators.
• Cell Biology & Signaling Studies: Employed to investigate the role of sphingomyelin and its metabolites in cell apoptosis, proliferation, differentiation, and stress responses.
• Diagnostic Reagent Manufacturing: Used in the formulation of calibrators and controls for clinical diagnostic assays measuring sphingolipid enzymes or metabolites.
• Academic Research: Essential for universities and research institutes conducting fundamental research on membrane biophysics, lipid rafts, and second messenger systems.

Basic Information

Product Name	n-Hexadecanoyl-D-Sphingosine-1-Phosphocholine
CAS No.	13053-57-1
Molecular Formula	C39H79N2O6P
Molecular Weight	703.03 g/mol
Synonyms	N-Palmitoyl-D-sphingosine-1-phosphocholine; N-Palmitoyl-sphingosylphosphorylcholine; Palmitoyl Sphingomyelin; C16:0 Sphingomyelin (d18:1/16:0); SM(d18:1/16:0); N-(Hexadecanoyl)-sphing-4-enine-1-phosphocholine; D-erythro-Sphingosine, N-(1-oxohexadecyl)-, 1-(dihydrogen phosphate) 2-(trimethylammonio)ethyl ester
EINECS	Contact for details

Quality Control

Our n-Hexadecanoyl-D-Sphingosine-1-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from techniques including HPLC, NMR, and MS. Our quality commitment aligns with the standards required for research and development in pharmaceutical and life science industries.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.