Description

D-Threo-Biopterin is a biologically significant, stereospecific isomer of the essential cofactor biopterin. This compound matters for its critical role in enzymatic processes, particularly as a cofactor for aromatic amino acid hydroxylases. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in enzyme studies, biochemical research, and as a reference standard.

Application

• Biochemical Research & Enzyme Studies: Used as a critical cofactor in studying the function of enzymes like phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in drug manufacturing and research.
• Diagnostic Reagent Component: Employed in the formulation of diagnostic kits and assays for metabolic disorders related to biopterin metabolism.
• Cell Culture & Neuroscience Research: Utilized in specialized cell culture media and research models investigating neurotransmitter synthesis and related pathways.
• Nutritional & Metabolic Studies: Applied in research focused on understanding the role of biopterins in human nutrition and metabolic diseases.

Basic Information

Product Name	D-Threo-Biopterin
CAS No.	13019-52-8
Molecular Formula	C₉H₁₁N₅O₃
Molecular Weight	237.22 g/mol
Synonyms	(6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one; (6R)-L-erythro-5,6,7,8-Tetrahydrobiopterin; D-Threo-5,6,7,8-Tetrahydrobiopterin; 6R-BH4; D-THBP; (6R)-5,6,7,8-Tetrahydro-L-biopterin; Sapropterin (as dihydrochloride salt); Schircks-6R-BH4
EINECS	Contact for details

Quality Control

Our D-Threo-Biopterin is produced and tested under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral identity confirmation, to ensure it meets high-grade specifications suitable for research and development. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area. Allow the product to reach room temperature in the sealed container before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-Threo isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.