Description

Fumitremorgin B CAS NO 12626-17-4 is a potent and specific mycotoxin belonging to the tremorgenic indole alkaloid class, known for its role as a highly effective inhibitor of the Breast Cancer Resistance Protein (BCRP/ABCG2). This compound matters significantly in pharmaceutical research and development, where it is utilized as a critical pharmacological tool to study drug efflux, multidrug resistance, and the blood-brain barrier. Researchers in oncology, neuropharmacology, and drug metabolism need this high-purity reference standard to advance their studies on chemotherapeutic resistance and central nervous system drug delivery.

Application

• Pharmacological Research Tool: Used extensively as a selective and potent inhibitor of the BCRP/ABCG2 transporter in in vitro and in vivo studies.
• Oncology & Drug Resistance Studies: Critical for investigating mechanisms of multidrug resistance in cancer cells and for screening potential compounds that can circumvent this resistance.
• Blood-Brain Barrier (BBB) Permeation Assays: Employed to assess the role of BCRP in limiting the brain penetration of therapeutic agents and toxins.
• Drug-Drug Interaction Studies: Utilized in preclinical ADME (Absorption, Distribution, Metabolism, Excretion) research to understand transporter-mediated interactions.
• Biochemical & Cell-Based Assay Development: Serves as a control and standard in developing high-throughput screening assays for BCRP activity.
• Reference Standard for Mycotoxin Analysis: Used as an analytical standard in food safety, environmental, and clinical toxicology testing for tremorgenic mycotoxins.

Basic Information

Product Name	Fumitremorgin B
CAS No.	12626-17-4
Molecular Formula	C27H33N3O5
Molecular Weight	479.57 g/mol
Synonyms	Fumitremorgin B; Fumitremorgin-B; FTM B; BCRP Inhibitor Fumitremorgin B; (3aS,10aR,10bS)-8,9-Dimethoxy-3a,10a,10b-trimethyl-1,2,3,3a,4,5,10,10a,10b,11-decahydro-7H-pyrrolo[2',3':4,5]pyrrolo[2,1-a]isoquinoline-3,6-dione; Tremorgenic Mycotoxin Fumitremorgin B; Ko 143 Precursor
EINECS	Contact for details

Quality Control

Our Fumitremorgin B is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and structural verification by spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.