Description

Ouabain Octahydrate is a highly specific cardiac glycoside and potent inhibitor of the Na+/K+-ATPase enzyme. This compound is a critical research tool for studying ion transport mechanisms, cellular signaling, and cardiovascular physiology. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic manufacturers for biochemical assays, pharmacological studies, and as a reference standard.

Application

• Biochemical Research: As a specific Na+/K+-ATPase inhibitor for studying ion pump function and cellular energetics.
• Pharmacology & Toxicology: Investigation of cardiotonic effects, drug interactions, and mechanisms of cardiac glycosides.
• Cell Signaling Studies: Used to probe intracellular signaling cascades triggered by changes in sodium and calcium ion concentrations.
• Reference Standard: Serves as a high-purity analytical standard in pharmaceutical quality control and method development.
• Diagnostic Reagent Manufacturing: A key component in certain in vitro diagnostic kits for research use.
• Neuroscience Research: Studying the role of Na+/K+-ATPase in neuronal function and neurodegenerative processes.

Basic Information

Product Name	Ouabain Octahydrate
CAS No.	11018-89-6
Molecular Formula	C29H44O12 • 8H2O
Molecular Weight	728.77 g/mol (Octahydrate)
Synonyms	G-Strophanthin; Acocantherin; Strophanthin G; Ouabain; 3β-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1β,5,11α,14,19-pentahydroxycard-20(22)-enolide octahydrate; NSC 22188; 1β,3β,5,11α,14,19-Hexahydroxy-5β-card-20(22)-enolide 3-(6-deoxy-α-L-mannopyranoside) octahydrate
EINECS	234-258-9

Quality Control

Our Ouabain Octahydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and water content. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	16.0% - 20.0% (Theoretical for octahydrate: ~19.8%)
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	-30° to -34° (c = 1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.