Description

Palmatine Chloride is a quaternary isoquinoline alkaloid salt known for its distinct yellow color and significant biological activity. This high-purity compound is valued for its role as a key reference standard and active pharmaceutical ingredient in research and development. It is primarily sought by the pharmaceutical, nutraceutical, and life science research industries for applications in metabolic, cardiovascular, and inflammatory studies. Our supply ensures consistent quality and reliable availability for critical B2B applications.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of therapeutic agents targeting various conditions.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate mechanisms related to diabetes, liver protection, and anti-inflammatory pathways.
• Natural Product Standardization: Used to standardize and quantify palmatine content in herbal extracts and traditional medicine formulations.
• Life Science Reagents: Incorporated into assay kits and research reagents for studying enzyme inhibition and cellular signaling.

Basic Information

Product Name	Palmatine Chloride
CAS No.	10605-02-4
Molecular Formula	C21H22ClNO4
Molecular Weight	387.86 g/mol
Synonyms	Palmatine hydrochloride; 2,3,9,10-Tetramethoxyprotoberberinium chloride; Berberine, 5,6-dihydro-9,10-dimethoxy-; Columbamine chloride; 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride; Coptisine chloride (related isomer); Natural Yellow 18 (historical context)
EINECS	234-231-4

Quality Control

Our Palmatine Chloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications. We support compliance with cGMP and ICH guidelines for relevant grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.