Description

β-Estradiol-3-Sulfate-17-Glucopyranosiduronic Acid Dipotassium Salt is a high-purity, conjugated metabolite of estradiol, a key endogenous estrogen. This compound is of significant value as a critical reference standard and analytical reagent for research and quality control in the life sciences. It is primarily required by pharmaceutical R&D laboratories, diagnostic manufacturers, and academic institutions for hormone metabolism studies, assay development, and method validation.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity assessment, and quantification of estradiol metabolites in drug development and quality control (QC/QA) processes.
• Clinical Research & Diagnostics: Serves as a calibrator and control in the development of immunoassays and LC-MS/MS methods for measuring hormone levels in biological samples.
• Metabolite Profiling: Essential for studying the Phase II conjugation pathways (sulfation and glucuronidation) of estradiol in pharmacokinetic and toxicological research.
• Endocrinology Research: A vital tool for investigating estrogen metabolism, receptor interactions, and related physiological or pathological processes.
• Biomarker Analysis: Employed in the accurate measurement of specific estrogen metabolites, which can serve as biomarkers for certain health conditions.

Basic Information

Item	Detail
Product Name	β-Estradiol-3-Sulfate-17-Glucopyranosiduronic Acid Dipotassium Salt
CAS No.	10392-35-5
Molecular Formula	C24H30K2O14S
Molecular Weight	668.75 g/mol
Synonyms	Estradiol 3-Sulfate 17-Glucuronide Dipotassium Salt; Estrone 3-Sulfate 17-Glucuronide Dipotassium Salt (common misnomer); 17β-Estradiol 3-Sulfate 17β-D-Glucuronide Dipotassium Salt; Estradiol-3-sulfate-17β-D-glucopyranosiduronic Acid Dipotassium Salt; E2-3S-17G; 3-Sulfooxy-17-[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(1-oxido-1-oxo-λ5-sulfanyl)oxy]oxan-2-yl]oxy-estra-1,3,5(10)-trien-17-ol Dipotassium Salt
EINECS	Contact for details

Quality Control

Our β-Estradiol-3-Sulfate-17-Glucopyranosiduronic Acid Dipotassium Salt is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for use as an analytical standard. Each batch undergoes rigorous quality testing, including HPLC for purity, spectroscopic identification (IR, NMR), and mass confirmation. Comprehensive Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.