Description

L-Leu-Leu-Leu is a high-purity synthetic tripeptide composed of three leucine amino acid residues. This compound serves as a critical biochemical tool and a key intermediate in advanced peptide synthesis and pharmaceutical research. It is essential for researchers and manufacturers in the fields of biochemistry, proteomics, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a standard, substrate, or inhibitor in enzymatic studies and proteolysis research.
• Pharmaceutical Intermediates: Acts as a key building block in the solid-phase and solution-phase synthesis of longer, more complex therapeutic peptides.
• Protease Specificity Studies: Employed to investigate the activity and specificity of various proteolytic enzymes like leucine aminopeptidases.
• Cell Biology: Utilized in studies of protein degradation pathways, including the ubiquitin-proteasome system.
• Nutraceutical Development: Serves as a precursor or model compound in the research of bioactive peptides for nutritional applications.
• Academic & Industrial R&D: A fundamental reagent for universities and contract research organizations (CROs) exploring peptide structure and function.

Basic Information

Product Name	L-Leu-Leu-Leu
CAS No.	10329-75-6
Molecular Formula	C18H35N3O4
Molecular Weight	357.49 g/mol
Synonyms	LLL; Leucyl-leucyl-leucine; H-Leu-Leu-Leu-OH; L-Leucyl-L-leucyl-L-leucine; Trileucine; N-(L-Leucyl)-L-leucyl-L-leucine; Leu-Leu-Leu tripeptide; 2-[[2-[[2-Amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoic acid
EINECS	233-714-4

Quality Control

Every batch of L-Leu-Leu-Leu is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research specifications, with comprehensive testing via HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing all quality parameters is provided with each shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-35° to -45° (c=1 in Acetic Acid)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.