Description

(3B,5B,7B,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid CAS NO 10322-18-6 is a key bile acid derivative, specifically a trihydroxylated cholanic acid, serving as a critical intermediate in pharmaceutical synthesis and biochemical research. Its value lies in its role as a precursor for the production of ursodeoxycholic acid (UDCA) and other therapeutic bile acids used to treat hepatobiliary disorders. This high-purity compound is essential for manufacturers in the pharmaceutical industry, research institutions developing liver therapeutics, and laboratories conducting metabolic studies.

Application

• Pharmaceutical Intermediate: Primary precursor in the synthesis of Ursodeoxycholic Acid (UDCA), a first-line treatment for primary biliary cholangitis and gallstone dissolution.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the manufacturing of other therapeutic bile acids and steroid-based pharmaceuticals.
• Biochemical Research: Serves as a standard or reagent in studies of bile acid metabolism, liver function, and cholesterol homeostasis.
• Cell Culture & Microbiology: Employed in specialized media and as a surfactant in certain biological assays and membrane studies.
• Reference Standard: Used as a high-purity certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Metabolic Pathway Investigation: A key compound for researching the enterohepatic circulation and the role of bile acids in digestion and signaling.

Basic Information

Product Name	(3B,5B,7B,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid
CAS No.	10322-18-6
Molecular Formula	C24H40O5
Molecular Weight	408.57 g/mol
Synonyms	Cholic Acid; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid; 3α,7α,12α-Trihydroxy-5β-cholanic Acid; 5β-Cholan-24-oic Acid-3α,7α,12α-triol; 3,7,12-Trihydroxycholanic Acid; Cholalic Acid; Colalin; Gallogen
EINECS	233-696-0

Quality Control

Our (3B,5B,7B,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and melting point, and specific tests for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmaceutical and research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Melting Point	197°C - 202°C
Assay (HPLC)	≥ 98.0%
Specific Rotation	+36° to +38° (c=1 in Ethanol)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.