Description

4-Ethoxy-1-Fluoro-2-Nitrobenzene is a versatile fluorinated aromatic nitro compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and an alkoxy substituent, makes it a valuable intermediate for constructing complex molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated aromatic rings.
• Agrochemical Synthesis: Used in the development of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex organic dyes and colorants.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination for creating biaryl structures.
• Liquid Crystal & OLED Development: Used in research for synthesizing fluorinated components of liquid crystal displays and organic light-emitting diodes.

Basic Information

Product Name	4-Ethoxy-1-Fluoro-2-Nitrobenzene
CAS No.	10298-81-4
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	1-Ethoxy-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitroanisole; 2-Nitro-4-fluoroanisole; 4-Ethoxy-2-nitrofluorobenzene; 1-Fluoro-4-ethoxy-2-nitrobenzene; 2-Nitro-4-fluorophenetole; p-Fluoro-o-nitroanisole; Benzene, 1-ethoxy-4-fluoro-2-nitro-
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-1-Fluoro-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.