Description

Corticosterone-21-Hemisuccinate is a key hemisuccinate ester derivative of the endogenous glucocorticoid corticosterone. This chemical modification enhances its solubility and makes it a crucial intermediate in the synthesis of more complex steroid conjugates and prodrugs. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents for hormone-related studies.

Application

• Pharmaceutical Intermediate: A vital building block in the synthesis of corticosterone prodrugs and other steroid-based therapeutic agents.
• Biochemical Research: Used as a standard or reagent in studies investigating glucocorticoid receptor activity, stress response pathways, and adrenal function.
• Diagnostic Kit Manufacturing: Serves as a hapten for the development of immunoassays and ELISA kits designed to detect and quantify corticosterone levels.
• Reference Standard: Employed in analytical laboratories for method development and validation in HPLC, LC-MS, or other chromatographic techniques.
• Conjugate Synthesis: The hemisuccinate group allows for covalent coupling to carrier proteins (e.g., BSA) for antibody production.
• Metabolic Studies: Used in research to trace and understand the metabolic pathways and conversion of corticosterone derivatives.

Basic Information

Product Name	Corticosterone-21-Hemisuccinate
CAS No.	10215-77-7
Molecular Formula	C25H34O7
Molecular Weight	446.53 g/mol
Synonyms	11β,21-Dihydroxypregn-4-ene-3,20-dione 21-hemisuccinate; Corticosterone 21-hemisuccinate; 21-Hemisuccinyloxycorticosterone; Corticosterone hydrogen succinate; B-21-HS; Reichstein's substance H hemisuccinate
EINECS	Contact for details

Quality Control

Our Corticosterone-21-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0%
Water Content (KF)	≤2.0%
Specific Rotation	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.