Description

Aristolochic Acid Sodium Salt is the sodium salt derivative of a naturally occurring nitrophenanthrene carboxylic acid. This compound is a critical reference standard and research chemical for toxicological and pharmacological studies due to its well-documented nephrotoxic and carcinogenic properties. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies engaged in safety testing, method development, and the study of herbal medicine contaminants.

Application

• Analytical Reference Standard: Primary use as a high-purity certified reference material (CRM) for qualitative and quantitative analysis in HPLC, LC-MS, and GC-MS.
• Toxicology Research: Essential for in vitro and in vivo studies investigating mechanisms of nephrotoxicity, carcinogenicity, and mutagenicity associated with aristolochic acids.
• Pharmaceutical Safety Testing: Used in quality control laboratories to test for the presence of this contaminant in herbal drug preparations and dietary supplements.
• Method Development & Validation: Serves as a key analyte for developing and validating sensitive analytical methods in compliance with regulatory guidelines for impurity detection.
• Biochemical Research: Employed in studies exploring DNA adduct formation, metabolic pathways, and cellular responses to toxic compounds.
• Forensic Analysis: Used as a standard in forensic toxicology to identify and quantify aristolochic acid derivatives in casework samples.

Basic Information

Product Name	Aristolochic Acid Sodium Salt
CAS No.	10190-99-5
Molecular Formula	C17H11NO7Na
Molecular Weight	364.27 g/mol
Synonyms	Aristolochic Acid A Sodium Salt; Sodium Aristolochate; Aristolochic Acid I Sodium Salt; 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic Acid Sodium Salt; Aristolochate Sodium; NSC 55486; Aristolochic Acid Sodium; Nitrophenanthrene Carboxylic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Aristolochic Acid Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and analytical applications. A detailed Certificate of Analysis (COA) providing batch-specific data from HPLC, NMR, and MS is supplied with every shipment to guarantee traceability and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.