Description

Thio-Nadh is a critical biochemical cofactor analog, widely recognized in research and industrial biocatalysis. This compound matters for its role in studying and manipulating enzymatic redox reactions, particularly those involving nicotinamide adenine dinucleotide (NADH)-dependent systems. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors who require high-purity cofactors for process development and analytical applications.

Application

• Biocatalysis Research: Used as a substrate or cofactor analog in enzymatic studies to investigate reaction mechanisms and enzyme kinetics.
• Pharmaceutical Intermediate Synthesis: Employed in the development and scaling of synthetic routes for active pharmaceutical ingredients (APIs) requiring specialized redox steps.
• Diagnostic Reagent Formulation: A key component in the formulation of diagnostic kits and assays for clinical and research laboratories.
• Enzyme Activity Assays: Serves as a critical reagent in spectrophotometric and fluorometric assays to measure dehydrogenase enzyme activity.
• Biochemical Standard: Used as a reference standard in analytical chemistry for quality control and method validation in related product manufacturing.
• Metabolic Pathway Studies: Applied in cellular and molecular biology research to probe NADH-dependent metabolic pathways.

Basic Information

Product Name	Thio-Nadh
CAS No.	1921-48-8
Molecular Formula	C21H29N7O14P2S
Molecular Weight	713.51 g/mol
Synonyms	Thionicotinamide Adenine Dinucleotide, Reduced Form; Thio-NADH; β-Nicotinamide Adenine Dinucleotide, Thio-Analog, Reduced; Adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with 1-(5-O-phosphono-β-D-ribofuranosyl)-1,4-dihydro-3-thionicotinamide; 1,4-Dihydro-3-thionicotinamide adenine dinucleotide; Reduced Thio-NAD; TNADH
EINECS	217-663-6

Quality Control

Our Thio-Nadh is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure high purity and consistency, meeting the exacting requirements of research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Absorbance Ratio (A260/A340)	≤ 2.5
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.