Description

6Beta-Fluoro-5Alpha,17,21-Trihydroxy-16Alpha-Methylpregnane-3,20-Dione 21-Acetate is a high-purity synthetic steroid derivative, serving as a critical advanced intermediate in pharmaceutical synthesis. Its precise fluorinated and hydroxylated structure is essential for developing potent corticosteroids with targeted therapeutic profiles. This compound is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel anti-inflammatory and immunosuppressive agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent fluorinated corticosteroid APIs, such as dexamethasone and betamethasone derivatives.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new steroidal drugs with enhanced efficacy and reduced side effects.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for steroid-based pharmaceuticals in GMP environments.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing of finished pharmaceutical products.
• Anti-inflammatory Drug Synthesis: Integral to creating active pharmaceutical ingredients (APIs) for treating conditions like arthritis, asthma, and dermatological disorders.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	6Beta-Fluoro-5Alpha,17,21-Trihydroxy-16Alpha-Methylpregnane-3,20-Dione 21-Acetate
CAS No.	1893-91-0
Molecular Formula	C₂₄H₃₅FO₆
Molecular Weight	438.53 g/mol
Synonyms	9α-Fluoro-11β,17α,21-Trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 6β-Fluoro-5α,17,21-trihydroxy-16α-methylpregnane-3,20-dione 21-acetate; 16α-Methyl-9α-fluoroprednisolone 21-acetate; Fluoroprednisolone acetate intermediate; Dexamethasone acetate related compound; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 6β-Fluoro-16α-methylprednisolone 21-acetate
EINECS	Contact for details

Quality Control

Our 6Beta-Fluoro-5Alpha,17,21-Trihydroxy-16Alpha-Methylpregnane-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.