Description

Dexamethasone 21-(Sodium Hydrogen Phosphate) is a water-soluble phosphate ester salt of the potent glucocorticoid dexamethasone. This chemical form is critical for enhancing bioavailability and stability in aqueous formulations, making it a preferred choice for injectable pharmaceutical products. It is primarily utilized in the pharmaceutical industry for the development and manufacturing of anti-inflammatory and immunosuppressive medications, including ophthalmic solutions and emergency injectables for severe allergic reactions.

Application

• Pharmaceutical Injectable Formulations: As a key active pharmaceutical ingredient (API) in solutions for intravenous, intramuscular, or subcutaneous administration.
• Ophthalmic Solutions: Used in eye drops and ointments for treating inflammatory eye conditions such as uveitis and allergic conjunctivitis.
• Anti-inflammatory & Immunosuppressive Therapies: For managing conditions like rheumatoid arthritis, severe allergies, asthma exacerbations, and certain autoimmune disorders.
• Veterinary Medicine: Employed in anti-inflammatory treatments for companion animals and livestock.
• Research & Development: Serves as a reference standard and biochemical tool in pharmacological and metabolic research studies.
• Hospital Emergency Kits: A vital component in emergency medications for treating anaphylaxis and cerebral edema.

Basic Information

Product Name	Dexamethasone 21-(Sodium Hydrogen Phosphate)
CAS No.	1869-92-7
Molecular Formula	C22H28FNa2O8P
Molecular Weight	516.39 g/mol
Synonyms	Dexamethasone Sodium Phosphate; Dexamethasone 21-Phosphate Disodium Salt; Dexamethasone Phosphate; Dexamethasone 21-(Disodium Phosphate); Dexamethasone 21-Phosphate; Dexamethasone 21-Phosphoric Acid Disodium Salt; Oradexon; Hexadrol Phosphate; Dexpak Taperpak
EINECS	217-479-5

Quality Control

Our Dexamethasone 21-(Sodium Hydrogen Phosphate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing specifications for identity, assay, purity, and related substances are available upon request. We can supply material compliant with various pharmacopeial standards, including USP and EP monographs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 8.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
pH (1% Solution)	7.5 - 9.0
Specific Rotation	+72° to +80° (c=1 in water)
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grades)
Sterility	Sterile (for sterile-filtered grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.