Description

2,4-Difluoro-5-Nitrobenzenesulfonyl Chloride is a high-value, multi-functional chemical intermediate essential for advanced organic synthesis. Its core value lies in its dual reactive sites—the sulfonyl chloride and the activated aromatic ring—which enable precise and efficient derivatization. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Dye & Pigment Manufacturing: Serves as a precursor for specialty dyes and functional colorants due to its nitro and sulfonyl chloride groups.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling and modifying biomolecules in research applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom chemical synthesis services targeting niche and proprietary compounds.

Basic Information

Product Name	2,4-Difluoro-5-Nitrobenzenesulfonyl Chloride
CAS No.	1780-83-2
Molecular Formula	C6H2ClF2NO4S
Molecular Weight	257.60 g/mol
Synonyms	5-Nitro-2,4-difluorobenzenesulfonyl chloride; 2,4-Difluoro-5-nitrobenzenesulfonyl chloride; 2,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-2,4-difluoro-5-nitrobenzene; Benzenesulfonyl chloride, 2,4-difluoro-5-nitro-; 5-Nitro-2,4-difluorophenylsulfonyl chloride
EINECS	217-217-5

Quality Control

Our 2,4-Difluoro-5-Nitrobenzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as bases, amines, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.