Description

[4As-(4Aα,5Aα,6β,12Aα)]-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-4-(Hydroxyimino)-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide is a complex, semi-synthetic tetracycline derivative of significant interest in pharmaceutical research and development. This compound matters for its potential as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of advanced antibiotic and antimicrobial agents. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutics targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation tetracycline-class antibiotics.
• Antimicrobial Research: Used as a reference standard or active compound in biochemical assays to study mechanisms of action against Gram-positive and Gram-negative bacteria.
• API Development: Investigated for formulation into active pharmaceutical ingredients for human and veterinary medicinal products.
• Biochemical Tool: Employed in microbiological and pharmacological research to understand bacterial protein synthesis inhibition.
• Standards and Calibration: Utilized to prepare high-purity analytical standards for quality control and regulatory testing in pharmaceutical labs.

Basic Information

Product Name	[4As-(4Aα,5Aα,6β,12Aα)]-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-4-(Hydroxyimino)-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide
CAS No.	1771-28-4
Molecular Formula	C₂₂H₂₃N₂O₁₀
Molecular Weight	475.43 g/mol
Synonyms	4-(Hydroxyimino)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-2-naphthacenecarboxamide; 4-(Hydroxyimino)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-2-naphthacenecarboxamide (4aS,5aS,6S,12aS)-isomer; 4-(Hydroxyimino)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-2-naphthacenecarboxamide (4aS-(4aalpha,5aalpha,6beta,12aalpha))-; Tetracycline derivative intermediate; 4-(Hydroxyimino)-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxynaphthacene-2-carboxamide
EINECS	Contact for details

Quality Control

Our [4As-(4Aα,5Aα,6β,12Aα)]-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-4-(Hydroxyimino)-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.