Description

(S)-Reticuline is a key benzylisoquinoline alkaloid of significant interest in advanced organic synthesis and pharmaceutical research. Its primary value lies in its role as a pivotal biosynthetic precursor in the pathway to a diverse range of complex natural products, including morphine and other bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for complex molecule synthesis and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Critical precursor in the semi-synthesis and biosynthetic studies of opioid alkaloids like morphine and codeine.
• Biochemical Research: Used as a standard and substrate in enzymology studies, particularly for investigating benzylisoquinoline alkaloid biosynthesis pathways.
• Natural Product Synthesis: Serves as a chiral building block for the total synthesis of complex isoquinoline-based natural products.
• Reference Standard: Employed as a high-purity analytical standard in HPLC and LC-MS for the identification and quantification of reticuline isomers in plant extracts and biological samples.
• Medicinal Chemistry: Provides a core scaffold for the design and development of novel therapeutic agents targeting neurological receptors.

Basic Information

Product Name	(S)-Reticuline
CAS No.	1699-46-3
Molecular Formula	C19H23NO4
Molecular Weight	329.39 g/mol
Synonyms	(S)-Reticuline; (S)-(-)-Reticuline; (-)-Reticuline; (1S)-1-[(3-Hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-7-ol; Reticuline, (-)-; L-Reticuline; NSC 407303; 7-Hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (S-form)
EINECS	Contact for details

Quality Control

Our (S)-Reticuline is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic methods (HPLC, LC-MS). We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-110° to -118° (c=1 in methanol)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.