Description

S-(Hydrogen 3-Hydroxy-3-Methylglutaryl)Coenzyme A is a key biochemical intermediate in the mevalonate pathway, essential for the biosynthesis of isoprenoids and sterols. This compound is critical for research and development in metabolic studies, particularly in understanding cholesterol regulation and enzyme kinetics. It is primarily utilized by biochemists, pharmaceutical researchers, and diagnostic manufacturers involved in enzymology, metabolic disorder research, and high-purity reagent production.

Application

• Enzymology Research: Serves as a specific substrate for HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, for kinetic and inhibition studies.
• Pharmaceutical R&D: Used in the development and screening of novel statin drugs and other therapeutic agents targeting the mevalonate pathway.
• Diagnostic Manufacturing: A critical component in the formulation of enzymatic assay kits for clinical diagnostics and research to measure HMG-CoA reductase activity.
• Metabolic Pathway Analysis: Essential for in vitro studies investigating isoprenoid biosynthesis, steroid hormone production, and related metabolic disorders.
• Biochemical Reference Standard: Employed as a high-purity calibrant or reference material in analytical laboratories for quality control and method validation.
• Academic Research: Used in university and institutional labs for fundamental research into cellular metabolism and lipid biochemistry.

Basic Information

Product Name	S-(Hydrogen 3-Hydroxy-3-Methylglutaryl)Coenzyme A
CAS No.	1553-55-5
Molecular Formula	C27H44N7O20P3S
Molecular Weight	911.66 g/mol
Synonyms	HMG-CoA; (S)-3-Hydroxy-3-methylglutaryl-CoA; 3-Hydroxy-3-methylglutaryl coenzyme A; Coenzyme A, S-(hydrogen 3-hydroxy-3-methylglutarate); 3-Hydroxy-3-methylglutaryl-CoA; β-Hydroxy-β-methylglutaryl-CoA; Mevalonate pathway intermediate; HMG-Coenzyme A
EINECS	Contact for details

Quality Control

Our S-(Hydrogen 3-Hydroxy-3-Methylglutaryl)Coenzyme A is produced under stringent quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90% (of theoretical activity)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water or appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.