Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregn-4-Ene-3,20-Dione 21-Acetate is a high-purity synthetic corticosteroid intermediate of significant pharmaceutical importance. Its value lies in its role as a key building block for the synthesis of potent anti-inflammatory and immunosuppressive steroid APIs, such as dexamethasone and related derivatives. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors who require reliable, high-quality raw materials for advanced drug development and production.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of high-potency glucocorticoids like dexamethasone and betamethasone.
• Anti-inflammatory Drug Production: Serves as a core structural component in the manufacture of active pharmaceutical ingredients (APIs) for treating inflammatory and autoimmune conditions.
• Research & Development: Used in medicinal chemistry research for developing new steroid-based therapeutics and studying structure-activity relationships (SAR).
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized steroid compounds.
• Reference Standard: Can be utilized as a chromatographic reference standard for quality control and analytical testing in pharmaceutical labs.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregn-4-Ene-3,20-Dione 21-Acetate
CAS No.	1549-35-5
Molecular Formula	C₂₄H₃₃FO₆
Molecular Weight	436.52 g/mol
Synonyms	9α-Fluoro-11β,17α,21-Trihydroxy-16β-methylpregna-4-ene-3,20-dione 21-acetate; 9α-Fluoro-16β-methylprednisolone 21-acetate; 9α-Fluoro-16β-methyl-1-dehydrocortisol 21-acetate; 16β-Methyl-9α-fluoroprednisolone 21-acetate; Dexamethasone 21-acetate intermediate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate (common misnomer); 1549-35-5; NSC 113927
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregn-4-Ene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical synthesis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every batch upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.