Description

(3R)-3-Hydroxy-5-(Hydroxy(Phosphonooxy)Phosphoryloxy)-3-Methylpentanoic Acid is a high-purity biochemical intermediate of significant interest in advanced pharmaceutical and life science research. This compound, a phosphorylated derivative of mevalonic acid, serves as a critical precursor in the study of isoprenoid biosynthesis pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on metabolic pathway analysis, enzyme inhibition studies, and the synthesis of novel therapeutic agents.

Application

• Biochemical Research: A key intermediate in the study of the mevalonate pathway and isoprenoid biosynthesis.
• Enzyme Substrate/Inhibitor Studies: Used to investigate the activity and kinetics of enzymes such as mevalonate kinase and phosphomevalonate kinase.
• Pharmaceutical Development: Serves as a building block for the synthesis of potential drug candidates targeting cholesterol synthesis and related metabolic disorders.
• Metabolomics & Pathway Analysis: Employed as a standard or tracer in metabolic flux analysis to understand cellular regulation.
• Academic Research: Utilized in universities and research institutes for fundamental studies in biochemistry and molecular biology.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(3R)-3-Hydroxy-5-(Hydroxy(Phosphonooxy)Phosphoryloxy)-3-Methylpentanoic Acid
CAS No.	1492-08-6
Molecular Formula	C6H14O11P2
Molecular Weight	324.11 g/mol
Synonyms	5-Diphosphomevalonic Acid; (R)-Mevalonic Acid 5-Diphosphate; (R)-5-Diphosphomevalonate; Mevalonate 5-Diphosphate; MVA-5-PP; (3R)-3-Hydroxy-3-methyl-5-(phosphonooxy)phosphoryloxypentanoic Acid; (R)-Mevalonate-5-diphosphate; 5-Pyrophosphomevalonic Acid
EINECS	Contact for details

Quality Control

Our (3R)-3-Hydroxy-5-(Hydroxy(Phosphonooxy)Phosphoryloxy)-3-Methylpentanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards utilizing techniques such as HPLC, NMR, and mass spectrometry to verify chemical structure and purity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be sealed under inert atmosphere or desiccant after opening to maintain stability and prevent hydrolysis. For long-term storage, keep frozen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.