Description

Desacetamidocolchicine is a key colchicine derivative and a significant intermediate in the synthesis of various bioactive compounds. This compound is valued for its role in pharmaceutical research and development, particularly in the study of microtubule dynamics and anti-inflammatory agents. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of colchicine analogs and related therapeutic agents.
• Biochemical Research: Used as a reference standard and tool compound in studies of tubulin binding and mitosis inhibition.
• Medicinal Chemistry: Serves as a versatile scaffold for the development of novel anti-gout and anti-inflammatory drug candidates.
• Academic Research: Employed in university and institutional labs for investigating cellular mechanisms and structure-activity relationships (SAR).
• Fine Chemical Production: An intermediate for manufacturing specialized, high-value chemicals for the life sciences sector.

Basic Information

Product Name	Desacetamidocolchicine
CAS No.	1420-08-2
Molecular Formula	C₂₁H₂₃NO₅
Molecular Weight	369.41 g/mol
Synonyms	Deacetylcolchicine; N-Desacetylcolchicine; Colchiceine Methyl Ether; 3-Demethylcolchicine; N-Desacetamidocolchicine; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide derivative; 7-Deacetamidocolchicine
EINECS	Contact for details

Quality Control

Our Desacetamidocolchicine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.