Description

Chaetomin is a complex fungal metabolite belonging to the epipolythiodioxopiperazine class of natural products. This compound is of significant interest in biochemical and pharmacological research due to its potent biological activities, including inhibition of hypoxia-inducible factor (HIF) and protein synthesis. It serves as a valuable reference standard and research-grade biochemical for scientists in pharmaceutical discovery, oncology research, and molecular biology, enabling the study of cellular pathways and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery programs.
• Oncology and Cancer Research: Employed as a biochemical tool to study hypoxia-inducible factor (HIF) pathways and investigate potential anti-cancer mechanisms.
• Molecular Biology Studies: Utilized in research to probe protein synthesis inhibition and understand specific eukaryotic cellular processes.
• Academic and Institutional Research: Serves as a critical reagent in university and contract research organization (CRO) laboratories for fundamental biological studies.
• Biochemical Assay Development: Acts as a known inhibitor in high-throughput screening (HTS) assays to identify new drug candidates or validate assay systems.

Basic Information

Product Name	Chaetomin
CAS No.	1403-36-7
Molecular Formula	C31H30N6O6S3
Molecular Weight	678.81 g/mol
Synonyms	Chaetomin; Chaetocin; NSC 169850; 12,12'-Dihydroxy-11,11'-dideoxyverticillin A; 3,10-Epidithio-3,10-dideoxy-1,8-dihydroxy-6-methyl-5a,11a-dideoxygliotoxin; Gliotoxin, 3,10-epidithio-3,10-dideoxy-1,8-dihydroxy-6-methyl-5a,11a-dideoxy-; (3S,3'S,5aR,5a'R,11aS,11a'S)-3,3'-Dimethyl-3,3',4,4'-tetrahydro-1,1',8,8'-tetrahydroxy-6,6'-dimethyl[3,3'-bi(epidithio)pyrazino[1,2-a]indole]-2,2',5,5'(1H,1'H)-tetraone
EINECS	Contact for details

Quality Control

Our Chaetomin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.