Description

Gramicidin is a potent polypeptide antibiotic complex, primarily composed of gramicidin A, B, C, and D, known for its selective ionophoric activity against gram-positive bacteria. Its unique mechanism of action, forming channels in cell membranes to disrupt ion gradients, makes it a critical tool in biochemical research and selective antimicrobial applications. This product is essential for researchers in microbiology, pharmaceutical development, and for manufacturers of specialized topical formulations and diagnostic reagents.

Application

• Biochemical & Microbiological Research: Used as a standard ionophore in studies of membrane biophysics, ion transport mechanisms, and bacterial cell lysis.
• Pharmaceutical Intermediates: Serves as a key starting material or active component in the development of certain topical antibiotic preparations and combination therapies.
• Cell Biology & Physiology: Employed in experimental protocols to modulate membrane potential and study cellular processes dependent on ion gradients.
• Diagnostic Reagents: Incorporated into selective culture media and diagnostic kits for the identification of specific bacterial strains.
• Veterinary Medicine: Used in certain topical treatments for animal health, particularly where targeted action against gram-positive organisms is required.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical and research laboratories.

Basic Information

Product Name	Gramicidin
CAS No.	1393-88-0
Molecular Formula	Typically refers to Gramicidin D (a mixture); C99H140N20O17 (for Gramicidin A)
Molecular Weight	~1882 g/mol (for Gramicidin A)
Synonyms	Gramicidin D; Gramicidin from Bacillus brevis; Gramicidin A,B,C,D mixture; Gramicidin S (Note: Gramicidin S is a distinct cyclic peptide); Tyrocidine mixture; Linear Gramicidin; Gramoderm; UNII-99XBG6F9SJ
EINECS	215-747-3

Quality Control

Our Gramicidin is produced and tested under a strict quality management system to ensure batch-to-batch consistency and reliability for research and industrial use. Each lot undergoes comprehensive analysis, including identification, purity assay, and microbiological activity testing. A detailed Certificate of Analysis (COA) documenting purity (typically >95% by HPLC), biological potency, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (Total Gramicidin content)
Water Content (KF)	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Biological Activity	Conforms to reference (Contact for details)
Microbial Limits	Meets specified criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.